Mm45289, a Potent Glycopeptide Antibiotic Which Interacts
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چکیده
MM45289 (A82846A, eremomycin), a glycopeptide antibiotic of the vancomycin type, was confirmed to have improved antibacterial activity over vancomycin. However its affinity (Ka) for the target site peptide mimetic diacetyl-L-lysyl-D-alanyl-D-alanine (DALAA)was 23-fold lower. Concentrations of DALAArequired to reverse the antibacterial activity of MM45289 were in the order of 10 to 50-fold higher than for vancomycin. These results have implications for both mode of action studies and mechanism-basedscreening strategies for this class of antibiotic.
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تاریخ انتشار 2006